PREDICTING AND DETECTING POLYPHARMACYRELATED DRUG INTERACTIONS AND FRAILTY : GERIATRICS

Background: Frailty is a situation that has become increasingly important in recent years. The study’s objective was to investigate the connection between frailty and drug-drug interactions brought on by polypharmacy in older adults. Methods: 180 older adults admitted from the family practice medicine department between January 2022 to June 2022 were included. People over the age of 65 who applied to the family medicine outpatient clinic were included in the study. Results: The most prevalent comorbidities were hypertension (71.6%), diabetes (31.1%), and arthrosis (19.4%) in individuals with polypharmacy-related drug-drug interactions, antihypertensive medicines had the most interactions across all interaction classes. Polypharmacy-related drug-drug interactions were found in 130 (72.2%) of 180 patients included in the study. Conclusions: In the study, the frailty score was found to be statistically significantly worse in the 65 years and older with polypharmacy-related drug-drug interactions, according to age, comorbidities, and the number of drugs.