Sildenafil is one of the most commonly prescribed drugs for male erectile function. Transient ischemic attack (TIA) and ischemic/hemorrhagic stroke cases with sexual activity have been reported after sildenafil intake. Here, we describe an ischemic cerebrovascular disease case with a history of hypertension (HT), diabetes mellitus (DM), Behçet's disease (BD) and who applied to the emergency department with the development of sudden vision loss after sildenafil use. The common use of sildenafil, especially in patients with comorbidities, should be kept in mind as it can lead to serious side effects. In patients with a history of cerebrovascular disease, questioning the use of the medication is crucial.